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Abstract #0066

Application of 3D High-resolution Multi-echo TOF-SWI Acquisition in Radiation-induced Cerebral Microbleeds at 3T

Xiaowei Zou 1 , Wei Bian 2 , Jonathan I. Tamir 3 , Suchandrima Banerjee 4 , Susan M. Chang 5 , Michael Lustig 3 , Sarah J. Nelson 1 , and Janine M. Lupo 1

1 University of California San Francisco, San Francisco, California, United States, 2 Radiology, Stanford University, Stanford, California, United States, 3 Electrical Engineering and Computer Science, University of California Berkeley, Berkeley, CA, United States, 4 Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States, 5 Neurological Surgery, University of California San Francisco, San Francisco, CA, United States

Radiation therapy is a widely utilized treatment for gliomas. However, it can result in collateral injury to normal-appearing brain tissue, such as the formation of cerebral microbleeds (CMBs). The ability to assess characteristics of CMBs in conjunction with the surrounding arterioles and venules would help to identify underlying vascular injury. In this study, a seven-echo sequence was implemented and optimized for multi-echo multi-contrast high-resolution vascular imaging at 3T within a clinically feasible scan time. The fitted R2* maps can differentiate small-size CMBs and cystic changes, demonstrating the potential benefit of this sequence in routine clinical evaluation of CMBs.

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