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Abstract #0068

Dose and Volume Effects of Radiation on White Matter in Children Treated for Medulloblastoma

Iska Moxon-Emre 1,2 , Eric Bouffet 1 , Michael D Taylor 1,2 , Normand Laperriere 2,3 , Michael Sharpe 2,3 , Suzanne Laughlin 1 , Nadia Scantlebury 1 , Nicole Law 1,2 , David Malkin 1,2 , Jovanka Skocic 1 , Logan Richard 1,2 , and Donald Mabbott 1,2

1 Hospital for Sick Children, Toronto, Ontario, Canada, 2 University of Toronto, Toronto, Ontario, Canada, 3 University Health Network, Toronto, Ontario, Canada

This study examined white matter (WM) in children treated for medulloblastoma with different clinically relevant radiation dose and boost volumes, using diffusion tensor imaging (DTI). We found that relative to controls, patients treated with higher doses and/or larger boost volumes show more compromised WM than patients treated with the least intensive therapy (i.e. reduced dose CSR and a boost limited to the tumor bed). This was particularly evident in the temporal lobes, a brain region encompassed by a lateral beam boost to the posterior fossa (PF). Our findings suggest the PF boost should be avoided whenever possible.

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