The Effect of Systemic Chemotherapy on White Matter Tracts Involved with Cognition in Children with NF1-Associated Optic Pathway Gliomas

Although chemotherapy has been associated with cognitive deficits and changes in white matter integrity, the effect of low-intensity chemotherapy (separate from surgery and radiation) has not been examined. We examined diffusion tensor imaging (DTI) in 12 age-matched pairs of children with neurofibromatosis type 1 and optic pathway glioma with or without exposure to low-intensity chemotherapy, and without exposure to surgery or radiation. Subjects exposed to low-intensity chemotherapy had decreased FA in tracts previously associated with cognitive deficits. Two subjects with DTI scans before and after exposure to chemotherapy showed decrease in FA over 1 year.

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