Abstract #0071
Tissue Mapping in Brain Tumors with Partial Volume Magnetic Resonance Fingerprinting (PV-MRF)
Anagha Deshmane 1 , Chaitra Badve 2 , Matthew Rogers 3 , Alice Yu 3 , Dan Ma 1 , Jeffrey Sunshine 2 , Vikas Gulani 2 , and Mark Griswold 2
1
Biomedical Engineering, Case Western Reserve
University, Cleveland, OH, United States,
2
Radiology,
University Hospitals, Cleveland, OH, United States,
3
School
of Medicine, Case Western Reserve University, Cleveland,
OH, United States
Magnetic resonance fingerprinting (MRF) can be used to
simultaneously map T1, T2 and off-resonance. It was
previously demonstrated that modeling single voxel MRF
signals as a weighted sum of evolutions from known
tissue types can be used to quantify subvoxel tissue
fractions in the brain and perform tissue segmentation.
Here MRF is used to estimate fractions of free fluid,
intra/extracellular water, and myelin water in brain
tumor patients with glioblastoma multiforme and
metastases. A significant difference in free fluid and
intra/extracellular water fraction was found in
perilesional white matter between the two patient
groups.
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