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Abstract #0071

Tissue Mapping in Brain Tumors with Partial Volume Magnetic Resonance Fingerprinting (PV-MRF)

Anagha Deshmane 1 , Chaitra Badve 2 , Matthew Rogers 3 , Alice Yu 3 , Dan Ma 1 , Jeffrey Sunshine 2 , Vikas Gulani 2 , and Mark Griswold 2

1 Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2 Radiology, University Hospitals, Cleveland, OH, United States, 3 School of Medicine, Case Western Reserve University, Cleveland, OH, United States

Magnetic resonance fingerprinting (MRF) can be used to simultaneously map T1, T2 and off-resonance. It was previously demonstrated that modeling single voxel MRF signals as a weighted sum of evolutions from known tissue types can be used to quantify subvoxel tissue fractions in the brain and perform tissue segmentation. Here MRF is used to estimate fractions of free fluid, intra/extracellular water, and myelin water in brain tumor patients with glioblastoma multiforme and metastases. A significant difference in free fluid and intra/extracellular water fraction was found in perilesional white matter between the two patient groups.

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