Parameterization of delayed contrast enhancement maps for the depiction of necrosis in glioblastoma
Mary A McLean 1 , Stephen J Price 2 , Ferdia A Gallagher 3 , and John R Griffiths 1
Cancer Research UK Cambridge Institute,
University of Cambridge, Cambridge, Cambridgeshire,
of Neurosurgery, University of Cambridge, Cambridge,
Cambridgeshire, United Kingdom,
of Radiology, University of Cambridge, Cambridge,
Cambridgeshire, United Kingdom
We investigated relationships between MR measures of
perfusion, diffusion, T2-hyperintensity, and metabolite
content in 7 newly-diagnosed gliomas at 3T.
Parameterized subtraction maps of high-resolution
T1-weighted images obtained ~5 and ~50 min after
gadolinium injection showed a non-enhanced tumour core,
correlating positively with lactate and negatively with
creatine and choline, as distinct from a late-enhancing
area which had a metabolic profile more similar to
active tumour. ADC and T2-hyperintensity correlated with
each other but not with either MRS or perfusion. Maps of
delayed enhancement may provide a useful high-resolution
surrogate for metabolic information, but further
validation is needed.
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