Abstract #0072
Parameterization of delayed contrast enhancement maps for the depiction of necrosis in glioblastoma
Mary A McLean 1 , Stephen J Price 2 , Ferdia A Gallagher 3 , and John R Griffiths 1
1
Cancer Research UK Cambridge Institute,
University of Cambridge, Cambridge, Cambridgeshire,
United Kingdom,
2
Dept
of Neurosurgery, University of Cambridge, Cambridge,
Cambridgeshire, United Kingdom,
3
Dept
of Radiology, University of Cambridge, Cambridge,
Cambridgeshire, United Kingdom
We investigated relationships between MR measures of
perfusion, diffusion, T2-hyperintensity, and metabolite
content in 7 newly-diagnosed gliomas at 3T.
Parameterized subtraction maps of high-resolution
T1-weighted images obtained ~5 and ~50 min after
gadolinium injection showed a non-enhanced tumour core,
correlating positively with lactate and negatively with
creatine and choline, as distinct from a late-enhancing
area which had a metabolic profile more similar to
active tumour. ADC and T2-hyperintensity correlated with
each other but not with either MRS or perfusion. Maps of
delayed enhancement may provide a useful high-resolution
surrogate for metabolic information, but further
validation is needed.
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