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Abstract #0073

Abnormal Tumor and Peritumor Vasculature and Metabolism Differentiate Primary from Metastatic Brain Tumors

Ingrid Digernes 1 , Frdric Courivaud 1 , Cathrine Saxhaug 2 , Marco C. Pinho 3 , Oliver M. Geier 1 , Einar Vik-Mo 4 , Knut Haakon Hole 5 , Grete Lovland 1 , Svein Are Vatnehol 1 , Torstein R. Meling 4 , Otto Rapalino 6 , Atle Bjornerud 1,7 , and Kyrre E. Emblem 1

1 The Intervention Centre, Oslo University Hospital, Oslo, Oslo, Norway, 2 Department of Radiology, Oslo University Hospital, Oslo, Norway, 3 Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75235, United States, 4 Department of Neurosurgery, Oslo University Hospital, Oslo, Norway, 5 Departement of Radiology, Oslo University Hospital, Oslo, Norway, 6 Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States, 7 Department of Physics, University of Oslo, Oslo, Norway

We have used Vessel Architectural Imaging to reveal mechanisms of vascular remodelling in tumor and regions of peritumoral edema by comparing results from gliobastomas(GBMs) and metastatic brain tumors(METs). We found that the relative oxygen saturation level in tumor and edema regions were significantly higher in GBMs compared to METs and that vessel calibres of GBMs were larger than those of METs in tumor. This suggests that there are marked differences in tumoral and peritumoral vascular microenvironments in primary and metastatic brain tumors and that advanced MRI techniques may give valuable insights into the mechanisms of angiogenesis and growth in brain tumor patients.

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