Abstract #0089
Evaluation of Spin-echo based sequences for MR Elastography of Liver with Iron overload
Bogdan Dzyubak 1 , Yogesh K. Mariappan 2 , Kevin J. Glaser 1 , Sudhakar K. Venkatesh 1 , and Richard L. Ehman 1
1
Radiology, Mayo Clinic, Rochester,
Minnesota, United States,
2
Philips
Healthcare, Bangalore, Karnataka, India
Magnetic Resonance Elastography (MRE) can measure the
shear stiffness of soft tissues and is clinically used
for hepatic fibrosis assessment. In liver pathologies
resulting in high iron deposition(Ex: hemochromatosis),
the typical gradient-echo MRE sequence can fail due to
low SNR. To address this issue, two spin-echo based
pulse sequences with short echo times have been
developed. On patients with no iron overload, these
modified sequences provide stiffness values that are in
good agreement with the standard MRE, indicating that
the current clinically used critical stiffness values
can continue to be used for liver fibrosis assessment in
patients with iron overload, when using these sequences
as well.
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