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Abstract #0089

Evaluation of Spin-echo based sequences for MR Elastography of Liver with Iron overload

Bogdan Dzyubak 1 , Yogesh K. Mariappan 2 , Kevin J. Glaser 1 , Sudhakar K. Venkatesh 1 , and Richard L. Ehman 1

1 Radiology, Mayo Clinic, Rochester, Minnesota, United States, 2 Philips Healthcare, Bangalore, Karnataka, India

Magnetic Resonance Elastography (MRE) can measure the shear stiffness of soft tissues and is clinically used for hepatic fibrosis assessment. In liver pathologies resulting in high iron deposition(Ex: hemochromatosis), the typical gradient-echo MRE sequence can fail due to low SNR. To address this issue, two spin-echo based pulse sequences with short echo times have been developed. On patients with no iron overload, these modified sequences provide stiffness values that are in good agreement with the standard MRE, indicating that the current clinically used critical stiffness values can continue to be used for liver fibrosis assessment in patients with iron overload, when using these sequences as well.

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