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Abstract #0090

Analysis of Clinical and Histopathological Changes That Influence Liver Stiffness measured by MR Elastography

Wen-Pei Wu 1,2 , Ran-Chou Chen 2,3 , Chen-Te Chou 1 , Chih-Wei Lee 1 , Cheng-In Hoi 2 , Yi-Chun Wang 2,4 , and Kwo-Whei Lee 1

1 Radiology, Chang-Hua Christian Hospital, Chang-Hua, Taiwan, Taiwan, 2 Biomedical Imaging and Radiological Science, National Yang-Ming Medical University, Taiwan, Taiwan, 3 Radiology, Taipei city Hospital, Taipei, Taipei, Taiwan, Taiwan, 4 Taoyuan general hospital ministry of health and welfare, Taiwan, Taiwan

Purpose The purpose of our study was to determine the influence of the histological or clinical parameters on liver stiffness (LS) measured by MRE. Methods 354 patients underwent MRE and histological examination during a 3-month interval. Clinical, laboratory data and histological parameters were recorded. The spleen volume was also measured using semiautomatic software. The influence of the parameters on the LS was investigated through uni- and multivariate standard regression. Results The univariate regression analysis showed age, etiology, fibrosis, activity, iron deposition, AST, ALT, total bilirubin, platelet and spleen size were significantly correlated with LS. In multiple regression analysis, three variables independently influenced LS: fibrosis, activity, and spleen size. The parameters together explained 58.7% of the variances of the LS, with fibrosis making the most unique contribution (26.0%). Conclusions The degree of liver fibrosis , activity and spleen size independently and significantly exaggerated LS.

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