Abstract #0090
Analysis of Clinical and Histopathological Changes That Influence Liver Stiffness measured by MR Elastography
Wen-Pei Wu 1,2 , Ran-Chou Chen 2,3 , Chen-Te Chou 1 , Chih-Wei Lee 1 , Cheng-In Hoi 2 , Yi-Chun Wang 2,4 , and Kwo-Whei Lee 1
1
Radiology, Chang-Hua Christian Hospital,
Chang-Hua, Taiwan, Taiwan,
2
Biomedical
Imaging and Radiological Science, National Yang-Ming
Medical University, Taiwan, Taiwan,
3
Radiology,
Taipei city Hospital, Taipei, Taipei, Taiwan, Taiwan,
4
Taoyuan
general hospital ministry of health and welfare, Taiwan,
Taiwan
Purpose The purpose of our study was to determine the
influence of the histological or clinical parameters on
liver stiffness (LS) measured by MRE. Methods 354
patients underwent MRE and histological examination
during a 3-month interval. Clinical, laboratory data and
histological parameters were recorded. The spleen volume
was also measured using semiautomatic software. The
influence of the parameters on the LS was investigated
through uni- and multivariate standard regression.
Results The univariate regression analysis showed age,
etiology, fibrosis, activity, iron deposition, AST, ALT,
total bilirubin, platelet and spleen size were
significantly correlated with LS. In multiple regression
analysis, three variables independently influenced LS:
fibrosis, activity, and spleen size. The parameters
together explained 58.7% of the variances of the LS,
with fibrosis making the most unique contribution
(26.0%). Conclusions The degree of liver fibrosis ,
activity and spleen size independently and significantly
exaggerated LS.
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