Meeting Banner
Abstract #0091

Hyperpolarized [1- 13 C]octanoate: a probe of myocardial -oxidation

Hikari A. I. Yoshihara 1,2 , Jessica A. M. Bastiaansen 2,3 , Magnus Karlsson 4 , Mathilde Lerche 4 , Arnaud Comment 2,5 , and Juerg Schwitter 1

1 Division of Cardiology and Cardiac MR Center, Lausanne University Hospital, Lausanne, Switzerland, 2 Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, 3 Department of Radiology, Lausanne University Hospital and University of Lausanne, Switzerland, 4 Albeda Research ApS, Copenhagen, Denmark, 5 Institute of Physics of Biological Systems, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland

The heart is fueled mainly by long-chain fatty acids. We report the in vivo myocardial metabolism of hyperpolarized [1- 13 C]octanoate, a medium-chain fatty acid. The hyperpolarized signal is short-lived in the blood, but a metabolite signal from [1- 13 C]acetylcarnitine was observed, indicating the uptake of octanoate into the mitochondria and its lower case Greek beta -oxidation to acetyl-CoA. Additional metabolite signals from [5- 13 C]glutamate, [5- 13 C]citrate and [1- 13 C]acetoacetate were occasionally observed. The acetylcarnitine signal relative to octanoate tended to be lower and more variable in fasted versus fed rats. This study demonstrates that hyperpolarized 13 C-labeled medium-chain fatty acids can be used as metabolic probes in the heart.

This abstract and the presentation materials are available to members only; a login is required.

Join Here