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Abstract #0092

Hyperpolarized 13 C-alpha-ketobutyrate, a pyruvate analog

Cornelius von Morze 1 , Robert A Bok 1 , Michael A Ohliger 1 , Daniel B Vigneron 1 , and John Kurhanewicz 1

1 Department of Radiology & Biomedical Imaging, UCSF, San Francisco, California, United States

In this work we demonstrate hyperpolarization and rapid in vivo enzymatic conversion of an endogenous structural analog of 13 C-pyruvate, 13 C-alpha-ketobutyrate, via lactate dehydrogenase (LDH). Based on prior non-MR work and our own initial results, this hyperpolarized probe may exhibit useful selectivity for LDHB-expressed isoforms of LDH, such as heart or kidney LDH.

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