Abstract #0092

Hyperpolarized 13 C-alpha-ketobutyrate, a pyruvate analog

Cornelius von Morze ¹ , Robert A Bok ¹ , Michael A Ohliger ¹ , Daniel B Vigneron ¹ , and John Kurhanewicz ¹

¹ Department of Radiology & Biomedical Imaging, UCSF, San Francisco, California, United States

In this work we demonstrate hyperpolarization and rapid in vivo enzymatic conversion of an endogenous structural analog of ¹³ C-pyruvate, ¹³ C-alpha-ketobutyrate, via lactate dehydrogenase (LDH). Based on prior non-MR work and our own initial results, this hyperpolarized probe may exhibit useful selectivity for LDHB-expressed isoforms of LDH, such as heart or kidney LDH.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.