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Abstract #0093

Slice Blipped EPI Trajectory for Compressed Sensing Acquisition of 3D Time Resolved Imaging of Hyperpolarized [1- 13 C]Pyruvate and [1- 13 C]Lactate

Benjamin J. Geraghty 1,2 , Justin Y.C. Lau 1,2 , Albert P. Chen 3 , William Dominguez-Viqueira 1 , and Charles H. Cunningham 1,2

1 Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada, 2 Dept. of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, 3 GE Healthcare, Toronto, Ontario, Canada

Spectral-spatial excitation can be used for rapid time resolved 3D acquisitions; however, maintaining adequate spatial and temporal resolution is limited by the required field-of-view coverage. Here, we demonstrate a slice blipped EPI compressed sensing acquisition strategy for accelerated 3D time resolved imaging of [1-13C]pyruvate and lactate across a large field-of-view. Image reconstructions of both retrospectively and prospectively 2X undersampled in vivo data is presented. Close agreement is shown between fully and undersampled lactate to pyruvate area under curve ratio.

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