Abstract #0111
Response of Quantitative MRI to Artificial Collagen Cross-linking of Articular Cartilage
Jari Rautiainen 1,2 , Mikko J. Nissi 1,2 , Elli-Noora Salo 3 , Harri Kokkonen 2,4 , Shalom Michaeli 5 , Silvi Mangia 5 , Olli Grhn 6 , Juha Tyrs 2,4 , and Miika T. Nieminen 1,3
1
Medical Research Center Oulu and Department
of Diagnostic Radiology, University of Oulu, Oulu,
Finland,
2
Department
of Applied Physics, University of Eastern Finland,
Kuopio, Finland,
3
Department
of Diagnostic Radiology, Oulu University Hospital, Oulu,
Finland,
4
Diagnostic
Imaging Center, Kuopio University Hospital, Kuopio,
Finland,
5
Center
for Magnetic Resonance Research, University of
Minnesota, MN, United States,
6
Department
of Neurobiology, A.I.Virtanen Institute for Molecular
Sciences, University of Eastern Finland, Kuopio, Finland
Aging of cartilage results in accumulation of advanced
glycation end products (AGEs), most notably collagen
cross-links in cartilage. Increased cross-linking of the
collagens makes cartilage more stiff and brittle. In
this study, sensitivity of quantitative MRI parameters
to artificial collagen cross-linking induced by L-threose
in bovine articular cartilage was evaluated. Artificial
cross-linking detectably changed the biophysical
properties of cartilage which were also detected with
MRI parameters. While T2 and dGEMRIC responded to the
treatment as expected, T1ρ relaxation time constants
showed unexpected increase, possibly attributed to an
increased cross-linked fraction characterized by the
slow motion or blocking of exchange-mediated relaxation.
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