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Abstract #0112

Validation of diffusion tensor imaging of articular cartialge in an animal model of posttraumatic osteoarthritis

Jose G Raya 1 , Ignacio Rossi 1 , Oran Kennedy 1 , Natalie Danna 1 , Bryan Beutel 1 , You Jin Lee 1 , and Thorsten Kirsch 1

1 NYU Langone Medical Center, New York, NY, United States

We validate DTI of articular cartilage in an animal model of posttraumatic osteoarthritis (PTOA). Eight New Zeeland white rabbits underwent anterior cruciate ligament transection (ACLT) on one of the hindlimbs and sham surgery in the contralateral limb. Rabbits were scarified at 4 (n=4) and 8 weeks (n=4) after surgery. Both joints underwent MRI (PD-weighted and DTI), micro-CT and histology with safranin O. We observe a trend of increased MD in the ACLT joints compared to the sham that was significant at 8 weeks. Changes in MD correlated with areas of PG loss in histology, that only show changes on PG

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