Effects of bath solutions on the quantitative determination of relaxation times in compressed articular cartilage by microscopic MRI

A new type of laminar appearance was found in the deep region of compressed articular cartilage at the magic angle by high-resolution MRI, but the origin of this appearance was unclear. Recently, the molecular origin of this loading-induced laminar layer in the deep cartilage was attributed to the GAG loss in cartilage. To investigate the characteristics of this additional low-intensity layer, quantitative MRI T1, T2, and T1ρ experiments were carried out under different orientations when the tissue was soaked in different soaking solution.

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