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Abstract #0120

Cartilage MR T1ρ and T2 quantifications: longitudinal reproducibility and variations using different coils and scanners at single and multi-sites

Xiaojuan Li 1 , Valentina Pedoia 1 , Deepak Kumar 1 , Drew Lansdown 1 , Cory Wyatt 1 , Julien Rivorie 1 , Narihiro Okazaki 1 , Dragana Savic 1 , Matthew F Koff 2 , Joel Felmlee 3 , Williams Steven 3 , and Sharmila Majumdar 1

1 University of California, San Francisco, CA, United States, 2 Hospital for Special Surgery, New York, NY, United States, 3 Mayo Clinic, Rochester, MN, United States

MR T1ρ and T2 mapping are promising techniques that have potential as early markers of cartilage degeneration. Currently, applications of cartilage T1ρ and T2 imaging in multicenter clinical trials are very limited. One impeding factor is the lack of documentation of potential variations of T1ρ and T2 introduced by different scanners, coils and sites. In this report, we evaluate the longitudinal reproducibility of T1ρ and T2, and the variation of T1ρ and T2 by using different scanners and coils at one site, and the reproducibility and cross-validation of T1ρ and T2 among three sites.

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