Abstract #0122
In vivo assessment of age-related white matter differences using T 2 * relaxation
Erika P. Raven 1,2 , Peter van Gelderen 2 , Jacco A. de Zwart 2 , Diana H. Fishbein 3 , John VanMeter 1,4 , and Jeff H. Duyn 2
1
Georgetown University, Washington, DC,
United States,
2
Advanced
MRI, LFMI, NINDS, NIH, Bethesda, MD, United States,
3
University
of Maryland School of Medicine, Baltimore, MD, United
States,
4
Georgetown
Center for Functional and Molecular Imaging, Washington,
DC, United States
Experimental data suggest that the susceptibility
effects of myelinated axons are best characterized by a
three-compartment model, representing water trapped
between myelin layers (myelin water), throughout the
interstitial space, and within the axonal lumen. By
examining cellular specific contributions of each
compartment, we predicted that adolescents would have
lower myelin water fractions in later-myelinating
regions (genu, frontal white matter), while an early-myelinating
region (splenium) would be comparable to adults. The
current sample did not detect significant differences in
myelin water amplitude for any region, possibly due to
reduced susceptibility contrast at 3T or
susceptibility-induced artifacts.
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