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Abstract #0122

In vivo assessment of age-related white matter differences using T 2 * relaxation

Erika P. Raven 1,2 , Peter van Gelderen 2 , Jacco A. de Zwart 2 , Diana H. Fishbein 3 , John VanMeter 1,4 , and Jeff H. Duyn 2

1 Georgetown University, Washington, DC, United States, 2 Advanced MRI, LFMI, NINDS, NIH, Bethesda, MD, United States, 3 University of Maryland School of Medicine, Baltimore, MD, United States, 4 Georgetown Center for Functional and Molecular Imaging, Washington, DC, United States

Experimental data suggest that the susceptibility effects of myelinated axons are best characterized by a three-compartment model, representing water trapped between myelin layers (myelin water), throughout the interstitial space, and within the axonal lumen. By examining cellular specific contributions of each compartment, we predicted that adolescents would have lower myelin water fractions in later-myelinating regions (genu, frontal white matter), while an early-myelinating region (splenium) would be comparable to adults. The current sample did not detect significant differences in myelin water amplitude for any region, possibly due to reduced susceptibility contrast at 3T or susceptibility-induced artifacts.

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