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Abstract #0125

Leveraging transverse relaxation processes and Dixon oscillations to achieve high-quality segmentation of bone marrow

Mukund Balasubramanian 1,2 , Delma Y. Jarrett 1,2 , and Robert V. Mulkern 1,2

1 Department of Radiology, Boston Children's Hospital, Boston, MA, United States, 2 Harvard Medical School, Boston, MA, United States

We demonstrate that gradient-echo sampling of single spin-echoes can be used to isolate the signal from bone marrow, with high-quality segmentation and surface reconstruction resulting from the application of simple post-processing strategies available on modern radiology workstations. Our approach exploits signal behavior due to reversible and irreversible transverse relaxation, in concert with "Dixon oscillations", i.e., signal oscillations due to chemical-shift interference effects. The resulting 3D reconstructions could prove useful for orthopedic surgical planning, providing an alternative to computed tomography (CT) in situations where eliminating exposure to ionizing radiation is a high priority, e.g., when imaging pediatric patients.

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