Significant alterations on T2-spectra observed in the calf of myopathic patients

1H-NMR relaxation in skeletal muscle is long known to be multiexponential and this has been demonstrated to reveal myowater distribution and exchange between histological compartments. The spectroscopic CPMG sequence allows the acquisition of T2-relaxation curves with echo-time sampling and SNR that are high enough to allow robust multiexponential analysis. This method allows extracting a T2-spectrum that characterizes the investigated volume in the muscle. We hypothesise that the analysis of T2-spectra in diseased tissue shall offer specificity to MRI T2 measurements by revealing the pathophysiological mechanisms underlying the observed alterations on the monoexponential T2-value.

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