Abstract #0126
Significant alterations on T2-spectra observed in the calf of myopathic patients
Ericky Caldas de Almeida Araujo 1 and Pierre G Carlier 1,2
1
NMR Laboratory, Institute of Myology, Paris,
le-de-France, France,
2
NMR
Laboratory, CEA/I2BM/MIRCen, Paris, le-de-France,
France
1H-NMR relaxation in skeletal muscle is long known to be
multiexponential and this has been demonstrated to
reveal myowater distribution and exchange between
histological compartments. The spectroscopic CPMG
sequence allows the acquisition of T2-relaxation curves
with echo-time sampling and SNR that are high enough to
allow robust multiexponential analysis. This method
allows extracting a T2-spectrum that characterizes the
investigated volume in the muscle. We hypothesise that
the analysis of T2-spectra in diseased tissue shall
offer specificity to MRI T2 measurements by revealing
the pathophysiological mechanisms underlying the
observed alterations on the monoexponential T2-value.
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