Abstract #0127
Endogenous assessment of diffuse myocardial fibrosis with T1ρ-mapping in patients with dilated cardiomyopathy
Joep van Oorschot 1 , Johannes Gho 1 , Sanne de Jong 1 , Aryan Vink 1 , Fredy Visser 2 , Jacques de Bakker 3 , Steven Chamuleau 1 , Peter Luijten 1 , Tim Leiner 1 , and Jaco Zwanenburg 1
1
University Medical Center Utrecht, Utrecht,
Utrecht, Netherlands,
2
Philips
Healthcare, Best, Noord-Brabant, Netherlands,
3
AMC,
Amsterdam, Netherlands
Quantitative methods such as T1 mapping and ECV mapping
provide information on diffuse fibrosis formation in
patients with DCM. Recently it was shown that a
significantly higher T1ρ is found in compact myocardial
fibrosis. Here we validate cardiac T1ρ-mapping in
patients with DCM, and correlate with ECV-mapping and
fibrosis histology. Three explanted hearts from DCM
patients were scanned and histological fibrosis was
compared to the corresponding T1ρ value, with a Pearson
correlation r=0.27. In vivo T1ρ-mapping was performed in
6 DCM patients, where a significantly higher T1ρ (59.54
ms) was found compared to healthy controls (503 ms).
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