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Abstract #0127

Endogenous assessment of diffuse myocardial fibrosis with T1ρ-mapping in patients with dilated cardiomyopathy

Joep van Oorschot 1 , Johannes Gho 1 , Sanne de Jong 1 , Aryan Vink 1 , Fredy Visser 2 , Jacques de Bakker 3 , Steven Chamuleau 1 , Peter Luijten 1 , Tim Leiner 1 , and Jaco Zwanenburg 1

1 University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 2 Philips Healthcare, Best, Noord-Brabant, Netherlands, 3 AMC, Amsterdam, Netherlands

Quantitative methods such as T1 mapping and ECV mapping provide information on diffuse fibrosis formation in patients with DCM. Recently it was shown that a significantly higher T1ρ is found in compact myocardial fibrosis. Here we validate cardiac T1ρ-mapping in patients with DCM, and correlate with ECV-mapping and fibrosis histology. Three explanted hearts from DCM patients were scanned and histological fibrosis was compared to the corresponding T1ρ value, with a Pearson correlation r=0.27. In vivo T1ρ-mapping was performed in 6 DCM patients, where a significantly higher T1ρ (59.54 ms) was found compared to healthy controls (503 ms).

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