Abstract #0137
Odor-evoked fMRI maps are coupled to calcium-sensitive dye imaging patterns of input activity in the olfactory bulb
Basavaraju G Sanganahalli 1 , Michelle R Rebello 2 , Peter Herman 1 , Gordon M Shepherd 3 , Justus V Verhagen 2,4 , and Fahmeed Hyder 1,5
1
Diagnostic Radiology, Yale University, New
Haven, CT, United States,
2
The
John B. Pierce Laboratory, Yale University, New Haven,
CT, United States,
3
Neurobiology, Yale
University, New Haven, CT, United States,
4
Neurobiology,
Yale University, CT, United States,
5
Biomedical
Engineering, Yale University, New Haven, CT, United
States
To improve functional understanding of odor-evoked
glomerular activity patterns revealed by BOLD signal and
to relate how input activities of glomeruli reflected by
calcium imaging relate to bulk neuropil activity of
fMRI, we designed a study to image the same rats with
fMRI first and then with calcium imaging. Excellent
correspondence between odor-evoked fMRI maps and
calcium-sensitive dye imaging patterns of input activity
suggests input activity is a dominant part of neuropilar
activity in glomeruli. In conclusion, multi-modal
functional imaging of rat olfactory bulb with odorant
stimulation provides new opportunities for gaining
insights into complexities of neuropilar activities.
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