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Abstract #0136

Characterizing cortical responses to the stimulation of single mechanoreceptive afferents using fMRI at 7 T

Rosa Maria Sanchez Panchuelo 1 , Rochelle Ackerley 2 , Paul Glover 1 , Richard Bowtell 1 , Francis McGlone 3 , Johan Wessberg 2 , and Susan Francis 1

1 University of Nottingham, Nottingham, United Kingdom, 2 University of Gothenburg, Gothenburg, Sweden, 3 Liverpool Johns Moore University, Liverpool, United Kingdom

We successfully performed microstimulation of single afferents in the environment of an ultra-high field (7T) MR scanner and collected high resolution fMRI data depicting the response to intraneural microstimulation (INMS). fMRI data were acquired during INMS of 11 different afferents across four subjects. We compare the cortical responses elicited by INMS of single afferents with those produced by mechanical stimulation of each afferents receptive field. We show that INMS and vibrotactile stimulation engage sensory related brain areas, and that INMS activates additional brain networks. INMS responses were localized within the expected area of digit representation in primary somatosensory cortex.

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