Abstract #0135
Frequency specific optogenetic recruitment of evoked responses in the somatosensory thalamocortical circuit
Alex T.L. Leong 1,2 , Russell W. Chan 1,2 , Patrick P. Gao 1,2 , Joe S. Cheng 1,2 , Jevin W. Zhang 1,2 , Shu-Juan J. Fan 1,2 , Kevin K. Tsia 2 , Kenneth K.Y. Wong 2 , and Ed X. Wu 1,2
1
Laboratory of Biomedical Imaging and Signal
Processing, The University of Hong Kong, Hong Kong, SAR,
China,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Hong Kong, SAR, China
Timing has been postulated as one of the most important
aspects of information processing in the brain, and
frequency is the most intuitive of the many timing
parameters. Thalamocortical circuits present a good
opportunity to comprehend the importance of timing due
to their well-known relay pathways to the cortex in all
sensory modalities. They have oscillations that are well
characterized through multisite electrical recordings
during wakefulness, sleep, anesthesia and task-driven
activity. The advent of optogenetics coupled with fMRI
enables an unprecedented opportunity to probe the
dynamics of the somatosensory thalamocortical circuit of
the rat in response to differing frequency stimulation.
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