Abstract #0134
Uncovering the Functional Network of Medial Prefrontal Cortex in Awake Rodents using Optogenetic fMRI
Zhifeng Liang 1,2 , Glenn D.R. Waston 2,3 , Kevin D. Alloway 2,3 , Gangchea Lee 1 , Thomas Neuberger 1 , and Nanyin Zhang 1,2
1
Dept. of Biomedical Engineering,
Pennsylvania State University, University Park, PA,
United States,
2
Center
for Neural Engineering, The Huck Institutes of Life
Sciences, Pennsylvania State University, University
Park, PA, United States,
3
Neural
and Behavioral Sciences, College of Medicine,
Pennsylvania State University, Hershey, PA, United
States
Medial prefrontal cortex (mPFC) plays a critical role in
cognition and emotion. However, mPFC functional networks
cross the whole brain remains elusive, particularly in
awake rodents. Here we combined optogenetics and
functional magnetic resonance imaging (opto-fMRI) to
reveal mPFC functional networks in awake rodents. We
found optogenetic stimulations in infralimbic cortex
(IL, part of mPFC) generated robust, reliable and
distributed activations in awake rats, which resembled
efferent anatomical projections of IL. The results
expanded the applicability of opto-fMRI from
sensorimotor to cognition-related networks in awake
rodents, which can be utilized to investigate
circuit-level mechanisms underlying mPFC-related brain
functions and behaviors.
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