Meeting Banner
Abstract #0133

Intrahippocampal and Hippocampal-Cortical Interactions Driven by Frequency Specific Optogenetic Stimulation

Russell W. Chan 1,2 , Alex T.L. Leong 1,2 , Joe S. Cheng 1,2 , Partick P. Gao 1,2 , Shu-Juan J. Fan 1,2 , Kevin K. Tsia 2 , and Ed X. Wu 1,2

1 Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, 2 Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China

Previous studies suggested that the intrahippocampal interactions may be governed by gamma oscillations, while hippocampal-cortical interactions might be directed by low frequency oscillation and/or sharp wave-ripple. However, exactly how different frequency contributes to large-scale intrahippocampal and hippocampal-cortical interactions remains largely unknown. In this study, optogenetic functional MRI was applied to investigate the frequency-dependent hippocampal network activity. Large-scale hippocampal and cortical activations were found during 40Hz and 1Hz stimulation, respectively. This is also the first study demonstrating large-scale and widespread hippocampal-cortical activity by driving CaMKIIa-positive cells in the dorsal hippocampus. This widespread hippocampal-cortical activity suggests that the generation of low frequency oscillation in the dorsal hippocampus can modulate cortical activity.

This abstract and the presentation materials are available to members only; a login is required.

Join Here