Abstract #0133
Intrahippocampal and Hippocampal-Cortical Interactions Driven by Frequency Specific Optogenetic Stimulation
Russell W. Chan 1,2 , Alex T.L. Leong 1,2 , Joe S. Cheng 1,2 , Partick P. Gao 1,2 , Shu-Juan J. Fan 1,2 , Kevin K. Tsia 2 , and Ed X. Wu 1,2
1
Laboratory of Biomedical Imaging and Signal
Processing, The University of Hong Kong, Hong Kong,
China,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Hong Kong, China
Previous studies suggested that the intrahippocampal
interactions may be governed by gamma oscillations,
while hippocampal-cortical interactions might be
directed by low frequency oscillation and/or sharp
wave-ripple. However, exactly how different frequency
contributes to large-scale intrahippocampal and
hippocampal-cortical interactions remains largely
unknown. In this study, optogenetic functional MRI was
applied to investigate the frequency-dependent
hippocampal network activity. Large-scale hippocampal
and cortical activations were found during 40Hz and 1Hz
stimulation, respectively. This is also the first study
demonstrating large-scale and widespread hippocampal-cortical
activity by driving CaMKIIa-positive cells in the dorsal
hippocampus. This widespread hippocampal-cortical
activity suggests that the generation of low frequency
oscillation in the dorsal hippocampus can modulate
cortical activity.
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