Spatial Correlations of Neurovascular Coupling Studied using Single Pulse Opto-fMRI
Jack A Wells 1 , Isabel N Christie 1 , Sergey Kasparov 2 , Alexander Gourine 3 , and Mark F Lythgoe 1
Centre for Advanced Biomedical Imaging,
University College London, London, London, United
of Physiology and Pharmacology, University of Bristol,
Bristol, United Kingdom,
Physiology & Pharmacology, University College London,
London, United Kingdom
Despite the widespread application of fMRI, questions
remain regarding the link between the measured BOLD
signal and the underlying changes in neural activity.
Here, we present a novel technique to investigate
spatial correlations of neurovascular coupling. We use a
single pulse of light (10ms) to modulate the volume of
optogenetically induced action potentials in the rat
cortex with concurrent fMRI. A directly proportional
relationship was observed between the volume of BOLD
response and the estimated volume of light-activated
brain tissue, a finding which has possible implications
for the design of future fMRI studies.
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