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Abstract #0132

Spatial Correlations of Neurovascular Coupling Studied using Single Pulse Opto-fMRI

Jack A Wells 1 , Isabel N Christie 1 , Sergey Kasparov 2 , Alexander Gourine 3 , and Mark F Lythgoe 1

1 Centre for Advanced Biomedical Imaging, University College London, London, London, United Kingdom, 2 Department of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom, 3 Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom

Despite the widespread application of fMRI, questions remain regarding the link between the measured BOLD signal and the underlying changes in neural activity. Here, we present a novel technique to investigate spatial correlations of neurovascular coupling. We use a single pulse of light (10ms) to modulate the volume of optogenetically induced action potentials in the rat cortex with concurrent fMRI. A directly proportional relationship was observed between the volume of BOLD response and the estimated volume of light-activated brain tissue, a finding which has possible implications for the design of future fMRI studies.

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