MRS and MRI-determined Hepatic Proton Density Fat Fraction: Comparison of ROI Sampling Methods in Patients with Type 2 Diabetes
Kim Nhien Vu 1 , Guillaume Gilbert 1,2 , Marianne Chalut 1 , Miguel Chagnon 3 , Gabriel Chartrand 4 , Jacques de Guise 4 , and An Tang 1
Radiology, University of Montreal, Montreal,
Healthcare Canada, Montreal, Qc, Canada,
and Statistics, University of Montreal, Montreal, Qc,
and Orthopaedics Research Laboratory (LIO), cole de
technologie suprieure, Montreal, Qc, Canada
Magnetic resonance spectroscopy (MRS) is widely accepted
as the noninvasive reference standard for liver fat
quantification. MRI-proton density fat fraction (PDFF)
is an emerging biomarker of liver fat that offers the
possibility to cover the entire liver volume.
Conventionally, MRI-PDFF is calculated by sampling
regions of interest (ROI). However, it is unclear how
various ROI sampling methods reported in the literature
would agree with the liver mean PDFF. In this study, we
assessed the fat distribution heterogeneity across
segments. We also examined the agreement between various
ROI sampling methods reported in the literature.
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