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Abstract #0153

Characterization of the Wallerian degeneration process in the rat spinal cord with DIAMOND and NODDI: comparison with histological obervations.

Damien Jacobs 1 , Benoit Scherrer 2 , Aleksandar Jankovski 3 , Anne des Rieux 4 , Maxime Taquet 1 , Bernard Gallez 4 , Simon K. Warfield 2 , and Benoit Macq 1

1 ICTEAM, Universite catholique de Louvain, Louvain-La-Neuve, Belgium, 2 Computational Radiology Laboratory, Boston Childrens Hospital, Massachusetts, United States, 3 Hopital universitaire Mont-Godinne, Universite catholique de Louvain, Godinne, Belgium, 4 LDRI, Universite catholique de Louvain, Brussels, Belgium

The purpose is to investigate, for diffusion compartment models (NODDI and DIAMOND), the variations of diffusion parameters after Wallerian degeneration in the rat spinal cord. The values of diffusion parameters for NODDI and DIAMOND provide different informations and both models are investigated in the case of the Wallerian degeneration process. The alterations of each diffusion parameters are highlighted after an unilateral rhizotomy and the results are compared with the histological observations (myelin, neurofilaments, microglia, astrocytes).

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