Abstract #0154
Quantitative histological correlates of NODDI orientation dispersion estimates in the human spinal cord
Francesco Grussu 1 , Torben Schneider 1 , Richard L. Yates 2 , Mohamed Tachrount 3 , Hui Zhang 4 , Daniel C. Alexander 4 , Gabriele C. DeLuca 2 , and Claudia A. M. Wheeler-Kingshott 1
1
NMR Research Unit, Department of
Neuroinflammation, Queen Square MS Centre, UCL Institute
of Neurology, London, England, United Kingdom,
2
Nuffield
Department of Clinical Neurosciences, University of
Oxford, Oxford, England, United Kingdom,
3
Department
of Brain Repair and Rehabilitation, UCL Institute of
Neurology, London, England, United Kingdom,
4
Department
of Computer Science and Centre for Medical Image
Computing, University College London, London, England,
United Kingdom
Neurite orientation dispersion is an important
morphological feature at the MRI voxel scale even in
coherent areas such as the corpus callosum. In this
work, we investigate its importance in another organised
area: the human spinal cord. We estimate orientation
dispersion in an
ex
vivo
specimen
with neurite orientation dispersion and density imaging
(NODDI) at 9.4 T, and compare results with structure
tensor features of silver stained sections from the same
sample. We conclude that orientation dispersion is a key
microstructural characteristic also of the spinal cord,
and NODDI is a reliable technique for its
quantification.
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