Meeting Banner
Abstract #0154

Quantitative histological correlates of NODDI orientation dispersion estimates in the human spinal cord

Francesco Grussu 1 , Torben Schneider 1 , Richard L. Yates 2 , Mohamed Tachrount 3 , Hui Zhang 4 , Daniel C. Alexander 4 , Gabriele C. DeLuca 2 , and Claudia A. M. Wheeler-Kingshott 1

1 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, England, United Kingdom, 2 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England, United Kingdom, 3 Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, England, United Kingdom, 4 Department of Computer Science and Centre for Medical Image Computing, University College London, London, England, United Kingdom

Neurite orientation dispersion is an important morphological feature at the MRI voxel scale even in coherent areas such as the corpus callosum. In this work, we investigate its importance in another organised area: the human spinal cord. We estimate orientation dispersion in an ex vivo specimen with neurite orientation dispersion and density imaging (NODDI) at 9.4 T, and compare results with structure tensor features of silver stained sections from the same sample. We conclude that orientation dispersion is a key microstructural characteristic also of the spinal cord, and NODDI is a reliable technique for its quantification.

This abstract and the presentation materials are available to members only; a login is required.

Join Here