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Abstract #0155

Validation of double diffusion schemes of microscopic fractional anisotropy

Henrik Lundell 1 , Tim B. Dyrby 1 , Penny L. Hubbard Cristinacce 2,3 , Feng-Lei Zhou 2,4 , Geoffrey J.M. Parker 2,3 , and Sune N. Jespersen 5,6

1 Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark, 2 Centre for Imaging Sciences, The University of Manchester, United Kingdom, 3 Biomedical Imaging Institute, The University of Manchester, United Kingdom, 4 The School of Materials, The University of Manchester, United Kingdom, 5 CFIN/MINDLab, Aarhus University, Denmark, 6 Department of Physics and Astronomy, Aarhus University, Denmark

Double diffusion encoding pulse sequences (also known as double PFG) have been shown to detect microscopic diffusion anisotropy in macroscopically isotropic systems. Here we present and validate three sets of gradient direction schemes to measure microscopic diffusion anisotropy (e.g. FA) in the presence of macroscopic anisotropy. In a phantom of co-electro-spun fibers, our results demonstrate similar performance of the three schemes, and show how FA and FA together inform about microscopic anisotropy and fiber dispersion in a model independent fashion.

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