Abstract #0155
Validation of double diffusion schemes of microscopic fractional anisotropy
Henrik Lundell 1 , Tim B. Dyrby 1 , Penny L. Hubbard Cristinacce 2,3 , Feng-Lei Zhou 2,4 , Geoffrey J.M. Parker 2,3 , and Sune N. Jespersen 5,6
1
Centre for Functional and Diagnostic Imaging
and Research, Copenhagen University Hospital, Hvidovre,
Denmark,
2
Centre
for Imaging Sciences, The University of Manchester,
United Kingdom,
3
Biomedical
Imaging Institute, The University of Manchester, United
Kingdom,
4
The
School of Materials, The University of Manchester,
United Kingdom,
5
CFIN/MINDLab,
Aarhus University, Denmark,
6
Department
of Physics and Astronomy, Aarhus University, Denmark
Double diffusion encoding pulse sequences (also known as
double PFG) have been shown to detect microscopic
diffusion anisotropy in macroscopically isotropic
systems. Here we present and validate three sets of
gradient direction schemes to measure microscopic
diffusion anisotropy (e.g. FA) in the presence of
macroscopic anisotropy. In a phantom of co-electro-spun
fibers, our results demonstrate similar performance of
the three schemes, and show how FA and FA together
inform about microscopic anisotropy and fiber dispersion
in a model independent fashion.
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