Meeting Banner
Abstract #0158

A processing pipeline and anisotropic diffusion phantom to calibrate DTI experiments

Alexandru V. Avram 1 , Michal E. Komlosh 1,2 , Alan S. Barnett 1,2 , Elizabeth Hutchinson 1,2 , Dan Benjamini 1,3 , and Peter J. Basser 1

1 Section on Tissue Biophysics and Biomimetics, NICHD, National Institutes of Health, Bethesda, MD, United States, 2 The Henry Jackson Foundation, Bethesda, MD, United States, 3 Department of Biomedical Engineering, Tel-Aviv University, Tel-Aviv, Israel

Experimental design and environmental factors can bias the quantitation of anisotropic diffusion using DTI-derived metrics, such as FA, compromising the value of longitudinal data and multicenter clinical studies. We propose the use of a novel anisotropic diffusion phantom in conjunction with a general method for modeling the diffusion signal produced by that phantom using the details of the DWI pulse sequence and the multiple correlation function (MCF) framework. The well-defined and known microstructure of the phantom generates a wide range of DTI parameters that can be used to calibrate various DTI pulse sequences and optimize clinical DTI protocols.

This abstract and the presentation materials are available to members only; a login is required.

Join Here