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Abstract #0168

Velocity and wall shear stress in the Circle of Willis in Sickle Cell Disease using 4D flow MRI

Lena Vaclavu 1 , Henk-Jan Mutsaerts 1 , Wouter Potters 1 , Veronica van der Land 1 , Karin Fijnvandraat 1 , Michael Markl 2 , Charles Majoie 1 , Aart Nederveen 1 , and Pim van Ooij 1

1 Academic Medical Center AMC, Amsterdam, Noord-Holland, Netherlands, 2 Radiology & Biomedical Engineering, Northwestern University, Chicago, IL, United States

Wall shear stress (WSS) is the tangential force exerted by the flowing blood on the endothelial wall and is dependent on the dynamic viscosity of blood. ). Endothelial dysfunction in SCD could be related to low WSS but this hasnt been studied in the circle of willis (CoW), whereas low WSS in carotid has been shown to be atheroprotective.SCD is associated with increased risk for stroke and vasculopathy and therefore serves as an interesting patient population to investigate in relation to WSS. In this pilot study, we explore the feasibility of 4D flow MRI and WSS estimation in the CoW, and the Middle Cerebral Artery.

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