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Abstract #0173

APOE ε4 Allele Status Influences Early Neurodevelopment

Justin M Remer 1 , Douglas C Dean III 1,2 , Jonathan O'Muircheartaigh 3 , Sara D'Arpino 1 , Holly Dirks 1 , and Sean C.L. Deoni 1,4

1 Advanced Baby Imaging Lab, School of Engineering, Brown University, Providence, RI, United States, 2 Waisman Lab for Brain Imaging and Behavior, University of Wisconsin, Madison, WI, United States, 3 Department of Neuroimaging, King's College London, Institute of Psychiatry, London, United Kingdom, 4 Department of Pediatric Radiology, Children's Hospital Colorado, Aurora, CO, United States

The apolipoprotein (APOE) ε4 allele, a main risk factor for late onset Alzheimers Disease, has been associated with neurological differences in infants in cross-sectional studies. Longitudinal myelin growth curves, in 223 infants and children grouped according to APOE genotype, exhibited differential white matter development in neuroanatomical regions related to Alzheimers Disease. Group differences in overall cognition were also observed between APOE ε4 carriers and noncarriers. Results suggest the ε4 allele plays an important role in early neurodevelopment, with both anatomical and cognitive brain alterations seen several decades before disease symptoms commonly occur.

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