Abstract #0173
APOE ε4 Allele Status Influences Early Neurodevelopment
Justin M Remer 1 , Douglas C Dean III 1,2 , Jonathan O'Muircheartaigh 3 , Sara D'Arpino 1 , Holly Dirks 1 , and Sean C.L. Deoni 1,4
1
Advanced Baby Imaging Lab, School of
Engineering, Brown University, Providence, RI, United
States,
2
Waisman
Lab for Brain Imaging and Behavior, University of
Wisconsin, Madison, WI, United States,
3
Department
of Neuroimaging, King's College London, Institute of
Psychiatry, London, United Kingdom,
4
Department
of Pediatric Radiology, Children's Hospital Colorado,
Aurora, CO, United States
The apolipoprotein (APOE) ε4 allele, a main risk factor
for late onset Alzheimers Disease, has been associated
with neurological differences in infants in
cross-sectional studies. Longitudinal myelin growth
curves, in 223 infants and children grouped according to
APOE genotype, exhibited differential white matter
development in neuroanatomical regions related to
Alzheimers Disease. Group differences in overall
cognition were also observed between APOE ε4 carriers
and noncarriers. Results suggest the ε4 allele plays an
important role in early neurodevelopment, with both
anatomical and cognitive brain alterations seen several
decades before disease symptoms commonly occur.
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