Abstract #0176
In-vivo lipid quantification in carotid plaques using multi-slice T2 mapping: histological validation
Luca Biasiolli 1,2 , Joshua T Chai 1 , Linqing Li 3 , Ashok Handa 4 , Peter Jezzard 3 , Robin P Choudhury 1 , and Matthew D Robson 2
1
AVIC, Radcliffe Department of Medicine,
University of Oxford, Oxford, United Kingdom,
2
OCMR,
Radcliffe Department of Medicine, University of Oxford,
Oxford, United Kingdom,
3
FMRIB,
Nuffield Department of Clinical Neurosciences,
University of Oxford, Oxford, United Kingdom,
4
Nuffield
Department of Surgical Sciences, University of Oxford,
Oxford, United Kingdom
Quantitative T2 mapping has recently emerged as a
promising alternative to multicontrast MRI for carotid
plaque characterization, as it can measure plaque MR
properties directly on a voxel by voxel basis and
discriminate between the lipid core and the surrounding
fibrous tissue. In this study we have developed and
validated a DANTE-MESE sequence for multi-slice T2
mapping and used it for in-vivo plaque lipid
quantification. We have demonstrated that our method is
strongly correlated with histology and can discriminate
between symptomatic and asymptomatic plaques, and hence
has a lot of potential for clinical application.
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