Abstract #0185
"Squashing the peanut": What it means for in-vivo cardiac DTI
Andrew D Scott 1,2 , Sonia Nielles-Vallespin 1,3 , Pedro Ferreira 1,2 , Laura-Ann McGill 1,2 , Dudley Pennell 1,2 , and David Firmin 1,2
1
NIHR Cardiovascular Biomedical Research
Unit, The Royal Brompton Hospital, London, United
Kingdom,
2
National
Heart and Lung Institute, Imperial College London,
London, United Kingdom,
3
National
Heart, Lung and Blood Institute, National Institutes of
Health, Bethesda, Maryland, United States
The effects of noise have been well described in
neurological DTI, but the specific effects on cardiac
DTI are less understood. We developed cardiac specific
simulations to demonstrate the effects of noise on
parameters derived from cardiac DTI at a range of
b-values. This framework was used to demonstrate the
benefits of averaging the complex rather than magnitude
data. Subsequently, an algorithm for complex averaging
of in-vivo data was developed and tested in a healthy
cohort. FA and MD are over-estimated at low b-values and
under-estimated at high b-values. Complex averaging
reduces under-estimation of MD and FA at high b-values.
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