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Abstract #0185

"Squashing the peanut": What it means for in-vivo cardiac DTI

Andrew D Scott 1,2 , Sonia Nielles-Vallespin 1,3 , Pedro Ferreira 1,2 , Laura-Ann McGill 1,2 , Dudley Pennell 1,2 , and David Firmin 1,2

1 NIHR Cardiovascular Biomedical Research Unit, The Royal Brompton Hospital, London, United Kingdom, 2 National Heart and Lung Institute, Imperial College London, London, United Kingdom, 3 National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States

The effects of noise have been well described in neurological DTI, but the specific effects on cardiac DTI are less understood. We developed cardiac specific simulations to demonstrate the effects of noise on parameters derived from cardiac DTI at a range of b-values. This framework was used to demonstrate the benefits of averaging the complex rather than magnitude data. Subsequently, an algorithm for complex averaging of in-vivo data was developed and tested in a healthy cohort. FA and MD are over-estimated at low b-values and under-estimated at high b-values. Complex averaging reduces under-estimation of MD and FA at high b-values.

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