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Abstract #0186

Diffusion-tensor imaging study of myocardial architecture of Situs Inversus and Situs Solitus mutant mouse hearts

Yijen Lin Wu 1,2 , Yu Chen 1 , XiaoQin Liu 1 , Fang-Cheng Yeh 3 , T. Kevin Hitchens 4 , George C Gabriel 1 , and Cecilia Wen Ya Lo 1

1 Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States, 2 Rangos Research Center Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 3 Psychology, Carnegie Mellon University, Pittsburgh, PA, United States, 4 Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, PA, United States

Normal human development results in an asymmetrical arrangement of the organs within the chest and abdomen, as referred to as Situs Solitus. Situs Inversus, a type of laterality defect, in which the organs of the chest and abdomen are arranged in a perfect mirror image reversal of the normal position. We used DTI to study the myocardial architecture of Pkd1l1-/- mutant mouse hearts, with either Situs Solitus or Situs Inversus phenotypes. Although the Situs Solitus mutant heart appears phenotypically normal, our DTI results show that it is showing more aberrant myocardial organization similar to those of Situs Inversus mutant heart.

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