Abstract #0186
Diffusion-tensor imaging study of myocardial architecture of Situs Inversus and Situs Solitus mutant mouse hearts
Yijen Lin Wu 1,2 , Yu Chen 1 , XiaoQin Liu 1 , Fang-Cheng Yeh 3 , T. Kevin Hitchens 4 , George C Gabriel 1 , and Cecilia Wen Ya Lo 1
1
Developmental Biology, University of
Pittsburgh, Pittsburgh, PA, United States,
2
Rangos
Research Center Imaging Core, Children's Hospital of
Pittsburgh of UPMC, Pittsburgh, PA, United States,
3
Psychology,
Carnegie Mellon University, Pittsburgh, PA, United
States,
4
Pittsburgh
NMR Center for Biomedical Research, Carnegie Mellon
University, Pittsburgh, PA, United States
Normal human development results in an asymmetrical
arrangement of the organs within the chest and abdomen,
as referred to as Situs Solitus. Situs Inversus, a type
of laterality defect, in which the organs of the chest
and abdomen are arranged in a perfect mirror image
reversal of the normal position. We used DTI to study
the myocardial architecture of Pkd1l1-/- mutant mouse
hearts, with either Situs Solitus or Situs Inversus
phenotypes. Although the Situs Solitus mutant heart
appears phenotypically normal, our DTI results show
that it is showing more aberrant myocardial organization
similar to those of Situs Inversus mutant heart.
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