Abstract #0187
Mechanical Activation Time Mapping in Heart Failure Patients with and without Myocardial Scar using Cine DENSE MRI
Daniel A Auger 1 , Sophia X Cui 1 , Xiao Chen 1 , Jeffrey W Holmes 1 , Kenneth C Bilchick 2 , and Frederick H Epstein 1,3
1
Department of Biomedical Engineering,
University of Virginia, Charlottesville, Virginia,
United States,
2
Department
of Medicine, Cardiovascular Medicine, University of
Virginia, Charlottesville, Virginia, United States,
3
Department
of Radiology and Medical Imaging, University of
Virginia, Charlottesville, Virginia, United States
The purpose of this study was to use MRI and other
methods to evaluate the relationship between mechanical
and electrical cardiac activation in patients with heart
failure (HF), a wide QRS complex, and the absence or
presence of myocardial scar. Cine DENSE MR strain
imaging methods were used to assess the delay in
mechanical activation time in patients with and without
scar. Results show good correlations between mechanical
and electrical activation times in both patient cohorts.
In patients with scar, the steeper slope of the
regression line may reflect a more complex
electromechanical substrate and altered
electro-mechanical coupling.
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