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Abstract #0193

Improving the Arterial Input Function in Dynamic Contrast Enhanced MRI by fitting the signal in the complex plane

Frank FJ Simonis 1 , Alessandro Sbrizzi 2 , Ellis Beld 1 , Jan JW Lagendijk 1 , and Cornelis AT van den Berg 1

1 Radiotherapy, UMC Utrecht, Utrecht, Utrecht, Netherlands, 2 Radiology, UMC Utrecht, Utrecht, Netherlands

Acquiring an accurate arterial input function (AIF) is essential in dynamic contrast-enhanced (DCE) MRI analysis. Determining AIFs using MR magnitude data faces challenges due to experimental difficulties such as inflow, B1 non-uniformity and saturation effects. However phase-based AIFs have problems estimating the baseline and the tail of the AIF. Here we demonstrate that fitting the enhancement data in the complex plane can be used in DCE AIF estimation to mitigate noise and bias that arise from solely using phase or magnitude data. The technique is applied to 3T DCE-MRI data of prostate cancer patients

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