Abstract #0193
Improving the Arterial Input Function in Dynamic Contrast Enhanced MRI by fitting the signal in the complex plane
Frank FJ Simonis 1 , Alessandro Sbrizzi 2 , Ellis Beld 1 , Jan JW Lagendijk 1 , and Cornelis AT van den Berg 1
1
Radiotherapy, UMC Utrecht, Utrecht, Utrecht,
Netherlands,
2
Radiology,
UMC Utrecht, Utrecht, Netherlands
Acquiring an accurate arterial input function (AIF) is
essential in dynamic contrast-enhanced (DCE) MRI
analysis. Determining AIFs using MR magnitude data faces
challenges due to experimental difficulties such as
inflow, B1 non-uniformity and saturation effects.
However phase-based AIFs have problems estimating the
baseline and the tail of the AIF. Here we demonstrate
that fitting the enhancement data in the complex plane
can be used in DCE AIF estimation to mitigate noise and
bias that arise from solely using phase or magnitude
data. The technique is applied to 3T DCE-MRI data of
prostate cancer patients
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