Should DSC-MRI based blood volume and vessel size measures be corrected for contrast agent T2 leakage effects?
Ashley M Stokes 1 and C. Chad Quarles 1
Institute of Imaging Science, Radiology and
Radiological Sciences, Vanderbilt University, Nashville,
TN, United States
Contrast agent (CA) leakage in tumors leads to
inaccurate spin echo (SE) cerebral blood volume (CBV)
and mean vessel diameter (mVD) measures in DSC-MRI.
Here, we propose a new strategy to correct for T
effects on T
This simple and efficient approach was validated in rat
tumor models by comparing uncorrected and corrected SE
CBV and mVD against reference values obtained with an
intravascular CA. Correction of both T
effects improved the reliability of SE CBV and mVD. This
highlights the need for comprehensive correction
techniques to more accurately represent non-leaky tumor
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