Should DSC-MRI based blood volume and vessel size measures be corrected for contrast agent T2 leakage effects?

Contrast agent (CA) leakage in tumors leads to inaccurate spin echo (SE) cerebral blood volume (CBV) and mean vessel diameter (mVD) measures in DSC-MRI. Here, we propose a new strategy to correct for T ₂ leakage effects on T ₁ -insensitive ΔR ₂ timecourses. This simple and efficient approach was validated in rat tumor models by comparing uncorrected and corrected SE CBV and mVD against reference values obtained with an intravascular CA. Correction of both T ₁ and T ₂ leakage effects improved the reliability of SE CBV and mVD. This highlights the need for comprehensive correction techniques to more accurately represent non-leaky tumor hemodynamics.

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