Abstract #0198
Quantification of Water Exchange between Intravascular and Extravascular Compartments using Independent Component Analysis
Hatef Mehrabian 1,2 , Anne L Martel 1,2 , Johann Le Floc'h 1 , Hany Soliman 1,3 , Arjun Sahgal 1,4 , and Greg J Stanisz 1,2
1
Physical Sciences, Sunnybrook Research
Institute, Toronto, Ontario, Canada,
2
Medical
Biophysics, University of Toronto, Toronto, Ontario,
Canada,
3
Odette
Cancer Centre, Sunnybrook Health Sciences Centre,
Toronto, Ontario, Canada,
4
Radiation
Oncology, Sunnybrook Health Sciences Centre, Toronto,
Ontario, Canada
Tumor response to therapy could be assessed using
imaging biomarker derived from DCE-MRI. We have
previously developed an independent component analysis
(ICA)-based algorithm to split DCE-MRI data into its
intravascular and extravascular compartments. The
objective of current study is to employ these
intravascular/extravascular signals in a two-compartment
relaxation model of MRI signal and calculate the water
exchange rates between these two compartments, as well
as the compartment sizes. Our results show that the
model can robustly estimate exchange parameters, and
that these parameters are more sensitive to changes in
the tumor due to radiotherapy compared to conventional
pharmacokinetic modeling.
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