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Abstract #0198

Quantification of Water Exchange between Intravascular and Extravascular Compartments using Independent Component Analysis

Hatef Mehrabian 1,2 , Anne L Martel 1,2 , Johann Le Floc'h 1 , Hany Soliman 1,3 , Arjun Sahgal 1,4 , and Greg J Stanisz 1,2

1 Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada, 2 Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, 3 Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada, 4 Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

Tumor response to therapy could be assessed using imaging biomarker derived from DCE-MRI. We have previously developed an independent component analysis (ICA)-based algorithm to split DCE-MRI data into its intravascular and extravascular compartments. The objective of current study is to employ these intravascular/extravascular signals in a two-compartment relaxation model of MRI signal and calculate the water exchange rates between these two compartments, as well as the compartment sizes. Our results show that the model can robustly estimate exchange parameters, and that these parameters are more sensitive to changes in the tumor due to radiotherapy compared to conventional pharmacokinetic modeling.

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