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Abstract #0199

Multi-compartment analysis on water dynamics in rat brain by heavy water perfusion

Zi-Min Lei 1 , Cheng-He Li 1 , Sheng-Min Huang 1 , Chin-Tien Lu 1 , Kung-Chu Ho 2 , and Fu-Nien Wang 1

1 Biomedical Engineering and Environmental Sciences, National Tsing Hua University, HsinChu, Taiwan, 2 Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan

In this study of rodent brain imaging, using a new strategy of monitoring heavy water tracer by the attenuation of 1H signal, we further re-investigate the heavy water dynamics with a multi-compartmental analysis method, and investigated the spatial distribution of fast and slow compartments of heavy water perfusion.

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