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Abstract #0200

Detection of cerebral NAD+ in humans at 7 T

Robin A. de Graaf 1 , Henk M. De Feyter 1 , Peter B. Brown 1 , Terence W. Nixon 1 , Douglas L. Rothman 1 , and Kevin L. Behar 1

1 MRRC, Yale University, New Haven, CT, United States

Nicotinamide adenine dinucleotide (NAD+) has a central role in cellular metabolism and energy production and is related to gene expression, calcium mobilization, aging, cell death and timing of metabolism via the circadian rhythm. The in vivo detection of NAD+ has traditionally been limited and has only recently been demonstrated on rat brain with 1H and 31P NMR spectroscopy. Here the detection of NAD+ by 1H NMR spectroscopy is extended to human brain at 7 T. Results are quantitatively compared to those obtained with in vivo 31P NMR spectroscopy.

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