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Abstract #0201

GABA concentration in the superior temporal gyrus predicts gamma-band oscillations and multisensory perception

Ralf Mekle 1 , Johanna Balz 2 , Julian Keil 2 , Yadira Roa-Romero 2 , Semiha Aydin 1 , Florian Schubert 1 , Bernd Ittermann 1 , Juergen Gallinat 3 , and Daniel Senkowski 2

1 Medical Physics, Physikalisch-Technische Bundesanstalt, Berlin, Germany, 2 Department of Psychiatry and Psychotherapy, Charit-Universittsmedizin, Berlin, Germany, 3 Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany

The integration of different sensory streams into a coherent, conscious percept is required for multisensory perception, where in human brain the superior temporal gyrus (STG) plays an important role. In this combined MRS-EEG study, the sound-induced flash illusion (SIFI) paradigm was applied to test the hypotheses that the GABA concentration in the STG predicts multisensory perception at the behavioral level and gamma-band activity during SIFI. MRS data were acquired using MEGA-PRESS at 3T, and EEG signals were recorded for 40 subjects. The hypotheses were confirmed, and a tight triangular relationship between GABA concentration, gamma-band oscillations, and multisensory perception was found.

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