Abstract #0202
About differences of the transverse relaxation time (T 2 ) of 18 brain metabolites in gray and white matter at 3T
Patrik Oliver Wyss 1,2 , Andreas Hock 1,3 , Milan Scheidegger 1,3 , Niklaus Zoelch 1 , Markus Rudin 1,4 , Spyros Kollias 2 , and Anke Henning 1,5
1
Institute for Biomedical Engineering, UZH
and ETH Zurich, Zurich, Zurich, Switzerland,
2
Institute
of Neuroradiology, University Hospital Zurich, Zurich,
Zurich, Switzerland,
3
Department
of Psychiatry, Psychotherapy and Psychosomatics Hospital
of Psychiatry, University of Zurich, Zurich, Zurich,
Switzerland,
4
Institute
of Pharmacology and Toxicology, University of Zurich,
Zurich, Zurich, Switzerland,
5
Max
Planck Institute for Biological Cybernetics, Tuebingen,
Germany
The precise assessment of transverse relaxation time
constant T
2
of
brain metabolites is a prerequisite for reporting
quantitative MR spectroscopy results. To reveal
differences of T
2
in
gray and white matter, echo time series data were
recorded in 91 healthy volunteer at 3T and evaluated
using ProFit2.0. Different T
2
relaxation times
in gray and white matter exist for mi, cho, naa, glu and
naag, which should be considered and precisely evaluated
for. Differences may show changes in degrees of freedom
and therefore may be used to reveal a variation of cell
compartments or interaction between molecules and
enzymes.
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