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Abstract #0202

About differences of the transverse relaxation time (T 2 ) of 18 brain metabolites in gray and white matter at 3T

Patrik Oliver Wyss 1,2 , Andreas Hock 1,3 , Milan Scheidegger 1,3 , Niklaus Zoelch 1 , Markus Rudin 1,4 , Spyros Kollias 2 , and Anke Henning 1,5

1 Institute for Biomedical Engineering, UZH and ETH Zurich, Zurich, Zurich, Switzerland, 2 Institute of Neuroradiology, University Hospital Zurich, Zurich, Zurich, Switzerland, 3 Department of Psychiatry, Psychotherapy and Psychosomatics Hospital of Psychiatry, University of Zurich, Zurich, Zurich, Switzerland, 4 Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Zurich, Switzerland, 5 Max Planck Institute for Biological Cybernetics, Tuebingen, Germany

The precise assessment of transverse relaxation time constant T 2 of brain metabolites is a prerequisite for reporting quantitative MR spectroscopy results. To reveal differences of T 2 in gray and white matter, echo time series data were recorded in 91 healthy volunteer at 3T and evaluated using ProFit2.0. Different T 2 relaxation times in gray and white matter exist for mi, cho, naa, glu and naag, which should be considered and precisely evaluated for. Differences may show changes in degrees of freedom and therefore may be used to reveal a variation of cell compartments or interaction between molecules and enzymes.

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