Abstract #0203
A comparison of MEGA-sLASER and STEAM for in vivo quantification of GABA at 7T
Chen Chen 1 , Peter Morris 1 , Susan Francis 1 , and Penny Gowland 1
1
Sir Peter Mansfield Imaging Centre (SPMIC),
University of Nottingham, Nottingham, Nottinghamshire,
United Kingdom
GABA detection at 7T (B1,max=15uT) using an optimised
long TE MEGA-sLASER spectral editing sequence was
compared with a conventional short TE STEAM sequence in
terms of 1) reproducibility and 2) measured
[GABA]/[Cr+]. This study showed that 1) the
intra-subject reproducibility of both methods was high
(CV%=5-6%); 2) the inter-subject reproducibility of
MM-corrected MEGA-sLASER was higher than STEAM,
especially when the GABA concentration was low; 3)
[GABA] ]/[Cr+] measured using both methods correlated
well (r=0.69, p=0.006).
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