A comparison of MEGA-sLASER and STEAM for in vivo quantification of GABA at 7T

GABA detection at 7T (B1,max=15uT) using an optimised long TE MEGA-sLASER spectral editing sequence was compared with a conventional short TE STEAM sequence in terms of 1) reproducibility and 2) measured [GABA]/[Cr+]. This study showed that 1) the intra-subject reproducibility of both methods was high (CV%=5-6%); 2) the inter-subject reproducibility of MM-corrected MEGA-sLASER was higher than STEAM, especially when the GABA concentration was low; 3) [GABA] ]/[Cr+] measured using both methods correlated well (r=0.69, p=0.006).

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