Improvement of 2-hydroxyglutarate detectability by optimized triple-refocusing at 3T in vivo

As a potential biomarker for clinical diagnosis and prognosis, in vivo 2HG detection in IDH mutated glioma patients with high specificity is important. Due to the extensively overlaps between 2HG signal at 2.25 ppm and GABA signal at 2.28 ppm, the estimation of 2HG is elusive when 2HG concentration is low (< 3mM). Here we present in vivo 2HG measurements without considerable GABA contamination achieved by 2HG optimized triple-refocusing at 3T.

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