Improvement of 2-hydroxyglutarate detectability by optimized triple-refocusing at 3T in vivo
Zhongxu An 1 , Sandeep Ganji 1 , Elizabeth A. Maher 1 , Dianne Mendelsohn 1 , Marco Pinho 1 , Kevin Choe 1 , and Changho Choi 1
University of Texas Southwestern Medical
Center, Dallas, Texas, United States
As a potential biomarker for clinical diagnosis and
prognosis, in vivo 2HG detection in IDH mutated glioma
patients with high specificity is important. Due to the
extensively overlaps between 2HG signal at 2.25 ppm and
GABA signal at 2.28 ppm, the estimation of 2HG is
elusive when 2HG concentration is low (< 3mM). Here we
present in vivo 2HG measurements without considerable
GABA contamination achieved by 2HG optimized
triple-refocusing at 3T.
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