Abstract #0207
In Vivo Detection of 13 C Labeling of Glutamate and Glutamine Using Proton MRS at 7T
Li An 1 , Shizhe Li 1 , Maria Ferraris Araneta 1 , Christopher Johnson 1 , James B Murdoch 2 , and Jun Shen 1
1
National Institute of Mental Health,
National Institutes of Health, Bethesda, MD, United
States,
2
Toshiba
Medical Research Institute USA, Mayfield Village, OH,
United States
In vivo
measurement
of glutamate (Glu) and glutamine (Gln) turnover can
provide valuable information on energy metabolism and
neurotransmission in the human brain. Since 7 Tesla
proton MRS has been shown to be capable of measuring
dynamic changes in Glu and Gln signal strength during
intravenously infusion of [U-
13
C
6
]glucose,
in this work, we evaluated the feasibility of
quantifying the time-courses of [4-
13
C]Glu
and [4-
13
C]Gln concentrations measured by 7
Tesla
1
H
MRS. It was shown that the time-course difference
spectra could be fitted very well using a linear
combination of a numerically simulated basis set.
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