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Abstract #0207

In Vivo Detection of 13 C Labeling of Glutamate and Glutamine Using Proton MRS at 7T

Li An 1 , Shizhe Li 1 , Maria Ferraris Araneta 1 , Christopher Johnson 1 , James B Murdoch 2 , and Jun Shen 1

1 National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States, 2 Toshiba Medical Research Institute USA, Mayfield Village, OH, United States

In vivo measurement of glutamate (Glu) and glutamine (Gln) turnover can provide valuable information on energy metabolism and neurotransmission in the human brain. Since 7 Tesla proton MRS has been shown to be capable of measuring dynamic changes in Glu and Gln signal strength during intravenously infusion of [U- 13 C 6 ]glucose, in this work, we evaluated the feasibility of quantifying the time-courses of [4- 13 C]Glu and [4- 13 C]Gln concentrations measured by 7 Tesla 1 H MRS. It was shown that the time-course difference spectra could be fitted very well using a linear combination of a numerically simulated basis set.

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