Abstract #0212
Application of quantitative, multimodal fMRI to the estimation of the cerebral metabolic response to CO 2 and a visual stimulus in hypoxia
Aaron Benjamin Simon 1 , Zachary Smith 2 , Richard Buxton 2 , and David Dubowitz 2
1
Bioengineering, University of California San
Diego, La Jolla, CA, United States,
2
Radiology,
University of California San Diego, La Jolla, CA, United
States
How does sustained hypoxia affect the brain oxygen
metabolism (CMRO
2
) response to a stimulus? We
applied a novel multimodal Bayesian approach for
estimating the CMRO
2
response
to stimuli in human subjects after 6 hrs, 2 days and 7
days of sustained hypoxia (3800m elevation, 12.5% O
2
).
The acute response to a CO
2
challenge
was a significant reduction in CMRO
2
, and
this did not change with up to a week of
acclimatization. In contrast, the CMRO
2
response
to a visual stimulus was significantly reduced for up to
2 days of sustained hypoxia, but recovered to the
normoxic response by 7 days.
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