Meeting Banner
Abstract #0212

Application of quantitative, multimodal fMRI to the estimation of the cerebral metabolic response to CO 2 and a visual stimulus in hypoxia

Aaron Benjamin Simon 1 , Zachary Smith 2 , Richard Buxton 2 , and David Dubowitz 2

1 Bioengineering, University of California San Diego, La Jolla, CA, United States, 2 Radiology, University of California San Diego, La Jolla, CA, United States

How does sustained hypoxia affect the brain oxygen metabolism (CMRO 2 ) response to a stimulus? We applied a novel multimodal Bayesian approach for estimating the CMRO 2 response to stimuli in human subjects after 6 hrs, 2 days and 7 days of sustained hypoxia (3800m elevation, 12.5% O 2 ). The acute response to a CO 2 challenge was a significant reduction in CMRO 2 , and this did not change with up to a week of acclimatization. In contrast, the CMRO 2 response to a visual stimulus was significantly reduced for up to 2 days of sustained hypoxia, but recovered to the normoxic response by 7 days.

This abstract and the presentation materials are available to members only; a login is required.

Join Here