Meeting Banner
Abstract #0211

Unravelling the neurochemical mechanism of positive and negative BOLD responses: a combined fMRI-fMRS study

Adam Berrington 1 , Andre Gouws 2 , Stuart Clare 1 , Peter Jezzard 1 , and Uzay Emir 1

1 FMRIB Centre, University of Oxford, Oxford, United Kingdom, 2 York Neuroimaging Centre, University of York, York, United Kingdom

We investigate neurochemical changes associated with the positive and negative BOLD response. Using a visual stimulus capable of generating PBR and NBR adjacently in visual cortex, along with a two-voxel spectroscopy sequence at 7T, we determine metabolite changes from resting baseline. The relative increase or decrease of certain metabolites e.g. glucose and glutamate, between NBR and PBR, hints at alternate metabolic processes behind either response. Baseline concentrations of GABA and glutamate are also found to correlate to negative BOLD strength suggesting a link between inhibition-excitation balance and BOLD response.

This abstract and the presentation materials are available to members only; a login is required.

Join Here