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Abstract #0214

The impact of normoxic and hyperoxic baseline periods in block paradigms of hypercarbic cerebrovascular reactivity studies

Carlos C. Faraco 1 , Jeroen C.W. Siero 2 , Megan K. Strother 1 , Daniel F. Arteaga 1 , and Manus J. Donahue 1

1 Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, TN, United States, 2 Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands

Identification of cerebrovascular compromise in the clinic is frequently performed using catheter angiography, which is insensitive to tissue-level hemodynamics and is sub-optimal for longitudinal monitoring. Alternatively, hypercarbic-normoxic BOLD fMRI may be used to assess cerebrovascular reactivity (CVR). As a significant proportion of patients for whom CVR assessment is desirable are hypoxic, and may be operating near reserve capacity, hypercarbic-hyperoxic (HC-HO) BOLD fMRI is advisable. However, HC-HO stimuli introduce several experimental confounds, including non-specific venous O2 rebinding to dHb. Here we demonstrate that administration of baseline HO, before HC-HO, resolves or reduces the drawbacks associated with HC-HO CVR-weighted BOLD imaging.

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