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Abstract #0215

Searching for a truly "iso-metabolic" gas challenge for the use in calibrated fMRI and cerebrovascular reactivity mapping

Shin-Lei Peng 1 , Harshan Ravi 1 , Min Sheng 1 , Binu Thomas 1 , and Hanzhang Lu 1

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States

Hypercapnia challenge has been proposed as a method for the calibration experiment because CO2 does not alter brain metabolism. However, the assumption that hypercapnia challenge is iso-CMRO2 has not been validated. This study is to investigate a gas challenge is truly iso-metabolic by adding a hypoxic component to the hypercapnic challenge (hypercapnic-hypoxia). We used TRUST MRI to monitor the subjects CMRO2 during hypercapnic-hypoxia challenge. Our data showed the neural suppression effect of hypercapnia appears to be nullified by the metabolic enhancement effect of hypoxia. We therefore propose hypercapnic-hypoxia is an iso-metabolic challenge that may be used for calibrated fMRI studies.

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